Jounce Therapeutics

Job Listings

Here are our current job openings. Please click on the job title for more information, and apply from that page if you are interested.

The system cannot access your location for 1 of 2 reasons:
  1. Permission to access your location has been denied. Please reload the page and allow the browser to access your location information.
  2. Your location information has yet to be received. Please wait a moment then hit [Search] again.


Jounce Therapeutics, Inc. is a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long-lasting benefits to patients through a biomarker-driven approach. Jounce currently has multiple development stage programs ongoing while simultaneously advancing additional early-stage assets from its robust discovery engine based on its Translational Science Platform. Jounce’s most advanced product candidate, vopratelimab, is a monoclonal antibody that binds to and activates ICOS, and is currently being studied in the SELECT Phase 2 trial. JTX-4014 is a PD-1 inhibitor intended for combination use in the SELECT trial and with Jounce’s broader pipeline. Jounce’s next development stage product candidate, JTX-8064, is a LILRB2 (ILT4) receptor antagonist shown to reprogram immune-suppressive tumor associated macrophages to an anti-tumor state. A Phase 1 trial evaluating JTX-8064 is planned to begin enrollment in the fourth quarter of 2020. Additionally, Jounce exclusively licensed worldwide rights to JTX-1811, a monoclonal antibody targeting CCR8 and designed to selectively deplete T regulatory cells in the tumor microenvironment, to Gilead Sciences, Inc. For more information, please visit www.jouncetx.com. www.jouncetx.com

Jounce is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service or any other class protected by state or federal law.

All applicants should be legally entitled to work for any employer in the U.S.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

Click column header to sort

Page 1 of 2

The Medical Affairs at Jounce is hiring! We are seeking a Medical Science Liaison. Jounce has had a strong Medical Science Liaison (MSL) team to support our advancing clinical and research programs since 2019.  The MSL position is an exciting opportunity to join a company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and may bring long lasting benefits to patients. The MSLs are highly trained Medical Affairs (MA) professionals with strong clinical and/or scientific backgrounds.     We expect MSLs to have excellent communication and presentation skills. MSLs should demonstrate a solid understanding of immune-oncology as a therapeutic disease area as well as knowledge of clinical trial sites and/or connections with oncology experts. The Medical Science Liaison functions as a field-based, scientific expert who engages health care professionals to exchange clinical, scientific, and research knowledge. By following regulatory and corporate guidelines, they will facilitate and build scientific relationships and collaborations with the medical/scientific community as well as support clinical study initiatives (including patient enrollment in clinical trials). This position interacts with local, regional, and national HCPs; societies; and organizations. Due to the early stage of development of multiple compounds, the MSL will be utilized heavily in supporting clinical operations and clinical development.    In addition to a world-class research organization, Jounce prides itself on a solid translational and reverse translation approach to clinical trials.  Currently (though that may change in the future), the focus is mostly on early clinical development (phase 1 and 2).  MSLs will need to have a solid understanding of translational approaches within clinical studies while interacting with key clinical experts in the field.    - Function as the primary point of contact in the field for Jounce Medical Affairs.  - Maintain clinical, scientific, and technical expertise in relevant Immuno-Oncology/Oncology disease state areas.  - Have a thorough understanding of Jounce clinical protocols and related procedures.  - Collaborate with clinical operations and clinical development to support the recruitment of clinical trials, identify potential new clinical trial sites, and serve as an on-site Jounce resource to study site staff participating in Jounce studies.   - Execute study enrollment plans and clinical trial site engagement activities.  - Develop and track key opinion leader (KOL) engagement plans - identify, develop, and maintain long-term collaborative relationships with KOLs within assigned region. Participate in medical & scientific exchanges with the medical/scientific community including advisory boards.  - Respond to and document unsolicited requests for information on Jounce clinical programs.  - Facilitate company sponsored trials and serve as a resource for investigator sponsored trial (IST) proposals. Provide medical/clinical teams with feedback and insights from interactions with KOLs and investigators.  - Facilitate research collaborations with key investigators including helping identify, establish, and maintain such collaborations.   - Represent the company at medical meetings through Medical Affairs’ Scientific Booth coverage and other related activities.  - Adhere to corporate SOPs and ensure vigilant compliance with relevant legal and regulatory guidelines governing scientific interactions with physicians and healthcare professionals across all activities, including those related to clinical trials, scientific interactions with internal and external groups, and responses to unsolicited requests for medical/scientific information.  - Consistently demonstrate a high standard of excellence in the management of assigned territory while also contributing to the success of colleagues and the MSL organization.  - MSLs must contribute to the achievement of organizational goals beyond the borders of a geographic territory. 
Job ID
2021-1257
Location
US-
Jounce Therapeutics is seeking an experienced translational immunologist to join the Translational Exploratory and Clinical Immunology team and contribute to the development of novel cancer immunotherapies. The successful candidate will be responsible for managing multiple aspects of biomarker assays in on-going clinical trials. They will be applying Flow Cytometry and other immunoassays to develop and execute on a predicative and pharmacodynamic biomarker strategy. As part of a multi-disciplinary team, they will be expected to proactively interact with project teams, external collaborators and drive lab-based research to bring best-in-class biomarker strategies to Jounce clinical programs. - Contribute scientific leadership to Jounce clinical programs, representing function within larger program team for vopratelimab development. - Gain subject matter expertise for on-going clinical biomarker assays for vopratelimab development in the SELECT trial and beyond. - Work cross-functionally within Research to identify and establish assays and technologies to support mechanistic studies and biomarker validation. - Manage and guide the development of SOPs for the central lab; manage the scientific review, QC and presentation of external vendor results. - Contribute to scientific rationale for combination strategy for Jounce pipeline programs. - Train and continuously develop scientists and associates in the Translational Exploratory Immunology group.
Job ID
2021-1256
Location
US-MA-Cambridge
This individual will report to the Chief Financial Officer and work closely with the executive team to establish and implement a successful Investor Relations strategy that articulates and supports the Company's business and scientific objectives to the investment community and other external audiences including the scientific community. They will also manage all external communications, including media and public relations (news and editorial coverage, press releases and articles); financial communications, strategic executive communications; and Company website communications. Will act as a Company spokesperson, promoting, enhancing, and projecting the organization's vision, brand and reputation to external stakeholders, with a primary focus on analysts and investors, and build new and manage existing relationships with the investment community and other outside influencers. - Continue to develop Jounce’s investor relations program to ensure a consistent, timely flow of information about Jounce to the investment communities and Company shareholders. Establish and maintain excellent relations with institutional investors, key retail investors and analysts - Understand the science, technology, pipeline and business strategy sufficiently to identify issues and effectively communicate with investors - Partner with the CEO, CMO and CFO to lead and manage the Company's participation on quarterly earnings calls, investment conference calls and in-house meetings, road shows, analyst days, and one-on-one meetings - Develop relationships and maintain regular communication with individual investors, covering analysts and select buy-side contacts to provide up to date information about events and market trends affecting the Company, with the goal of communicating our long-term vision - Manage the Company's corporate communications via the Company website, social media channels, etc. Update and continuously improve the corporate website and social media efforts ensuring that key messages and communications are consistent - Lead strategic communications development, including, developing communications plan to take advantage of key Company milestones, preparing press releases, presentation decks, and earnings releases, creating management Q&As, conference call scripts, and business descriptions/other information for securities filings, and the Company website - Serve as a primary person to handle incoming inquiries from the media and investors - Establish strong internal relationships and effective communication with supporting business, scientific, and medical leadership within the organization - Manage an external set of advisors to successfully meet group objectives - Person should be comfortable with being hands-on and operating within a lean budget
Job ID
2021-1255
Location
US-MA-Cambridge
The Office Administration team at Jounce is hiring! We are seeking an Office Administrator who will serve as the first point of contact for the Company and will set the tone of the reception area for visitors. She/he will be responsible for the office environment including managing supplies, ordering food and organizing companywide events. The ideal candidate will be warm, welcoming, outgoing and highly organized. This position requires polished communication skills, exceptional attention to detail, good judgment, and the ability to manage within a very dynamic, fast-paced environment, with constantly evolving priorities. We are looking for a team player who is energetic, proactive and hardworking. This role will require onsite presence 5 days a week during business hours (9 a.m. – 5 p.m. ET). - Greet, register and direct visitors to appropriate parties; active presence at the front desk for majority of the workday required. - Answer phones and direct calls accordingly. - Sort and deliver incoming mail. - Track, order and maintain storage areas for office supplies. - Manage food and kitchen supply program including monitoring and ordering snacks and groceries, receiving and unpacking weekly and daily food deliveries, and overall upkeep of refrigerators and snack area. - Collect, organize and update content for Company intranet site. - Assist Human Resources with onboarding/offboarding process. - Create and maintain security badges. - General administrative team and back-up support. - Assist with companywide events including happy hours, Company meetings, offsites, etc. and responsible for conference room and common area upkeep. - Order swag for new hires and companywide events / yearly Company gift.
Job ID
2021-1254
Location
US-MA-Cambridge
Jounce is seeking a talented IT professional to lead our IT team. This is a great opportunity to work with cutting edge Information Technology supporting Jounce’s mission to cure cancer! As the Head of IT you will be responsible for setting the strategy and managing Jounce IT Infrastructure, Information Security, and End User Services (EUS). Jounce IT provides a full suite of IT services to the company leveraging enterprise technologies and best practices. You will partner with business groups to develop and maintain an IT roadmap aligned with Jounce’s business strategy. You will have the opportunity to modernize infrastructure leveraging on-prem, cloud, and virtual technologies. The Head of IT will be responsible for managing direct reports, contractors, and IT vendors. This is an exciting role that combines integral projects and transformational technology. The right candidate will combine relevant experience both in the life sciences industry and publicly traded companies.      Responsibilities - Delivering IT services to the business using a right sized approach for Jounce’s needs. - Managing a high performing IT team, associated contract personel, and key vendor relationships.  Setting goals for team development and nurturing a high performing collaborative environment.  Supervising staff to ensure daily responsibilities are completed. - Interface with G&A business units to understand their goals and IT needs - Maintaining a high standard of customer service as the face of IT services. - Ensuring Jounce data and it’s intellectual property are stored securely and Jounce adheres to best practice standards for information security. - Oversight for IT compliance (i.e. SOX, GxP, Data Privacy). - Optimize and maintain business continuity and disaster recovery practices. - Laying out the strategy for Jounce IT services supporting both Research, Development, and G&A functions. - Developing and managing the IT roadmap and budget. - Executing IT projects on time and on-budget. - Contributing to the company culture within IIOT and cross-functionally at Jounce. - Setting IT standards and policies to ensure compliance and best practices.
Job ID
2021-1253
Location
US-MA-Cambridge
We are seeking an experienced paralegal and contracts manager to join our in-house legal department as Jounce continues to advance its robust clinical and pre-clinical product candidates. The Paralegal / Contracts Manager will provide support to members of the Legal Department and the business functions, including preparing agreements using internal templates and communicating with external parties regarding agreements.  The Paralegal / Contracts Manager will also provide support for ad hoc projects within the Legal Department. Responsible for all aspects of contract administration and contracts process support within Jounce’s Legal Department, including operation and maintenance of the contract management system software and database and general record-keeping for the contracts function.  The Paralegal / Contracts Manager’s responsibilities include: - Negotiating, drafting and facilitating the execution of template-based contracts, including non-disclosure agreements, consulting agreements, clinical trial agreements, services agreements and statements of work with attorney oversight - Directly communicating with in-house business partners and external counterparties during contract negotiations with respect to timelines, status and gating items - Appropriately escalating contract issues to in-house counsel and business partners as required - Coordination of the approval/signature process for contracts, including preparation of execution copies, signature collection from appropriate signatories, monitoring the status of contracts in the signature process, and scanning and routing signed contracts - Generating reports and performing record updates in the contracts database as needed, including monitoring contract lifecycle events such as expiration - Creation and maintenance of educational content and user guides about the self-service parts of the database and contract request process - Ability to work independently and collaboratively and - High level of confidentiality and discretion in handling of legal matters
Job ID
2021-1252
Location
US-MA-Cambridge
The Protein Production Group at Jounce Therapeutics is looking for an individual experienced in mammalian cell culture, protein purification, and characterization. The successful candidate will play an important role in the discovery and development of novel biotherapeutics for immuno-oncology.  He/she will be responsible for the production and purification of antibodies and other proteins for use in R&D that will enable the development of groundbreaking therapies. He/she will be expected to participate in experimental design, conduct experiments, optimize throughput, maintain detailed records, and participate in cross-functional collaborations.  This is an exciting opportunity to be part of a collaberative and fun team within the fast-paced and dynamic field of immuno-oncology.   Responsibilities: - Transient protein production in mammalian cell lines - Protein purification including affinity chromatography, ion-exchange chromatography and size-exclusion chromatography - Protein characterization methods including SE-HPLC, SDS-PAGE, and endotoxin assay - Employing liquid handling robots in the protein production process at smaller scales - Utilizing automated platforms to generate transfection-grade plasmid DNA - Thorough documentation and cross-functional communication
Job ID
2021-1251
Location
US-MA-Cambridge
The Antibody Discovery and Protein Engineering group at Jounce Therapeutics is looking for an exceptional scientist in antibody discovery and engineering.   The successful candidate will play a critical role in the discovery and development of novel biotherapeutics for immuno-oncology at Jounce Therapeutics.  In this role you will be responsible for leading antibody discovery and screening campaigns to obtain a diversified set of therapeutic leads.  Additionally, you will execute laboratory research and design structure-based antibody and protein engineering solutions to optimize lead molecules.  Through individual contributions in the lab and opportunity to manage a report, you will instrumental for mentoring great science at Jounce.  This is a unique opportunity to work cross-functionally as part of Jounce research program teams and make an impact on the company pipeline.   Responsibilities: - Support the therapeutic strategy and design antibody discovery strategies using a variety of techniques (hybridoma/display/B cell selection) through internal and external research - Design recombinant antibody, multispecifics, and target protein expression constructs to supply necessary reagents for program execution across Research functions - Perform screening assays for therapeutic antibody lead selection for binding and selectivity - Characterize target proteins and antibody interactions using high resolution cell and protein binding techniques - Design and test engineering solutions using computational and structure-based design (humanization, liability corrections, multi-specific formatting and innovative protein fusion designs) - Communicate efficiently and perform program leadership responsibilities focusing on protein science deliverables
Job ID
2021-1250
Location
US-MA-Cambridge
Jounce Therapeutics is seeking an experienced translational scientist to join the Translational Pathology team and contribute to the development of novel cancer immunotherapies. The successful candidate will be responsible for managing multiple aspects of preclinical and clinical development of biomarker assays and applying histologic techniques and image analysis to better understand the tumor micro-environment. As part of a multi-disciplinary team, they will be expected to proactively interact with project teams and external collaborators to provide insights and brainstorm ideas on how histologic techniques can be applied to advance Jounce programs.   Responsibilities: - Contribute scientific and subject matter expertise to Jounce programs from early discovery to clinical stage. - Provide insights and support in histology, immunohistochemistry, RNA in situ hybridization and other tissue-based assays to programs. - Work cross-functionally with other Research functions to identify and establish assays and technologies to support mechanistic studies and biomarker validation. - Lead improvement of current processes withing the Pathology groups, and evaluate novel technologies and modalities with the potential to impact Jounce discovery platform and pipeline. - Manage and guide the development of SOPs for the central lab; manage the scientific review, QC and presentation of external vendor results.  - Write, update, and provide training on laboratory SOPs, provide input on SAP, and data transfer agreements and clinical study reports.  - Train and continuously develop scientists in the pathology group. 
Job ID
2021-1249
Location
US-MA-Cambridge
This full-time position in the legal department at Jounce Therapeutics will support the company’s contracting activities.  The primary focus of this role is to provide legal contracting support, including project management, for Jounce’s clinical trial activities.    Responsibilities: - Reviewing, drafting and negotiating a variety of contracts with external parties to support the company’s clinical and research operations, including clinical trial agreements, confidentiality agreements, service agreements, statements of work, consulting agreements, amendments and change orders; reviewing and negotiating informed consent forms - Assisting in the preparation of clinical contract templates, including clinical trial agreements and informed consent forms - Establishing and managing workflows for confidentiality agreements needed for enrollment feasibility studies and site initiation, clinical trial agreements and informed consent forms - Acting as a single point of contact for, and providing sound guidance to, the clinical team, other internal and external stakeholders on clinical contract matters, informed consent forms and Jounce contracting standards - Attending clinical team meetings as legal representative and proactively managing the contractual and related legal needs for the clinical trials - Performing timely and accurate tracking and record-keeping of contracts in the contract management system and document management system, and acting as a legal approver of contracts in the company’s contract process - Collaborating cross-functionally to proactively manage and address the contractual needs of internal stakeholders in each contract - Coordinating with, and escalating issues to, the manager of contract operations as needed to ensure alignment with the company’s contracting standards, timeliness of contracting activities and operational sufficiency - Assisting with special projects as needed, including compliance initiatives, implementation of contract process changes, development of contracting standards and contract project management
Job ID
2021-1248
Location
US-MA-Cambridge
Jounce is looking for an experienced Associate Scientist/ Senior Associate Scientist specializing in In Vitro biology to join our Discovery Immuno-Oncology team. The successful candidate will be an experienced and highly motivated laboratory researcher engaged in the discovery and testing of novel cancer immunotherapeutic biologics. S/he will generate data to support key decisions for project teams and will also participate in the decision-making by sharing her/his expertise and perspective. Responsibilities include designing, developing, and conducting experiments aimed at identifying optimal therapeutic candidates and understanding the mechanism of action of our therapeutic molecules (mostly monoclonal antibodies). S/he will have the opportunity to work independently and collaboratively to advance portfolio programs in a dynamic and fast-paced environment.   Responsibilities: - Perform various in vitro immune cell culture assays, immunophenotyping by multi-color flow cytometry, intracellular cytokine staining, ELISA and multiplex technologies, proliferation assays and primary immune cell isolation - Perform screening assays for therapeutic lead selection - S/he will be responsible for data analysis, thorough documentation of work, and clear communication of results in group settings - Work cross-functionally as part of internal multi-disciplinary project teams - Maintain a safe and clean laboratory environment following all precautions for working in a BSL2/BSL2+ laboratory.
Job ID
2021-1247
Location
US-MA-Cambridge
The Protein Analytical group at Jounce Therapeutics is looking for an individual with expertise in antibody therapeutics, especially in the fields of antibody characterization/developability assessment and biophysical characterization.   This is an exciting opportunity to play an important role in the discovery and development of novel biotherapeutics for immuno-oncology.  The successful candidate will be the protein analytical lead on project teams, lead experimental design, conduct experiments, optimize throughput, maintain detailed records, develop new technology, and generate standard operating procedures and reports.  In this role you will have the opportunity to work cross functionally across multiple departments including discovery/biology, pre-clinical, Ab technology, protein production and CMC.The ideal candidate will have strong protein biochemistry and antibody discovery knowledge and be proficient at designing and executing lab experiments.   Responsibilities: - Act as key point person in protein characterization/developability assessment teams - Be the protein analytical lead on project team to provide analytical support and participate and present in project meetings. - Monitor and maintain equipment and instruments regularly to ensure proper operation and calibration. - Prepare SOPs and reports - Independently lead and develop new experiments, technological or scientific processes - Proactively share skills/knowledge with others to broaden company capabilities - Take a leadership role within the lab - 75% Laboratory based
Job ID
2021-1246
Location
US-MA-Cambridge
The Protein Analytical group at Jounce Therapeutics is looking for an individual with experience in protein characterization and antibody developability assessment. The successful candidate will play an important role in the discovery and development of novel biotherapeutics for immuno-oncology.  He/she/they will be expected to participate in experimental design, conduct experiments, optimize throughput, maintain detailed records, and generate standard operating procedures.  This is an exciting opportunity to play an important role in the discovery and development of novel biotherapeutics for immuno-oncology.  In this role you will have the opportunity to work cross functionally across multiple departments including discovery/biology, pre-clinical, Ab technology, protein production and CMC. The ideal candidate will have protein biochemistry and antibody discovery knowledge and be proficient at designing and executing lab experiments.   Responsibilities - Act as key point person in protein characterization/developability assessment teams - Monitor and maintain equipment and instruments regularly to ensure proper operation and calibration. - Prepare SOPs and reports - Independently lead and develop new experiments, technological or scientific processes - Proactively share skills/knowledge with others to broaden company capabilities - Take a leadership role within the lab - 100% laboratory based
Job ID
2021-1245
Location
US-MA-Cambridge
Jounce Therapeutics is looking a for a Senior Specialist, Quality Assurance to join a highly experienced team dedicated to transforming the treatment of cancer. The ideal candidate will have a strong understanding of regulatory requirements and industry standards to support daily GxP activities for clinical stage programs. This position will own Employee Training and spearhead document control and batch records across clinical programs.   Requirements: - Lead QA Document Control and GxP Employee Training records through collaboration with key stakeholders in identifying phase-appropriate SOPs, and continued development of GxP employee training program. - Contribute to the generation, review and/or approval of internal and external documents used in GMP activities such as, but not limited to, master batch records, stability protocols/ reports, specifications, deviations, change controls etc. - Perform batch disposition and other relevant document management activities - Track and monitor QA performance metrics and data to drive continuous improvements of internal processes. Generate and evaluate data to support Key Performance Indicators. - Provide QA CMC Operations support for end to end supply chain coverage. This includes quality & compliance support of manufacturing, testing, packaging/ labeling and distribution activities by CMOs for Jounce’s drug substance and drug product global operations (i.e., Product Specifications, Batch Records, Deviations, Investigations, Change Control, QA Lot Disposition, Stability, Retest/Expiration Extensions, termperature excursions, Analytical Method Qualification/Validation). - Ensure that Jounce products meet defined quality standards through batch record review and facilitation of product-related investigations.  - Support external vendor audits, including oversight of vendor management program as needed. - Support eQMS implementation and converstion of current QMS to eQMS in a streamlined process to include training of systems - Other QA related job duties as needed with shifting of priorities - Minimum of Bachelor's degree in science (e.g., biology, chemistry, pharmacy, medical, engineering or related field).
Job ID
2021-1244
Location
US-MA-Cambridge
The ideal candidate will oversee laboratory activities for the discovery and evaluation of novel cancer immunotherapeutic candidates. This person will play an integral role in conducting experiments to support pre-clinical and clinical teams, evaluating and implementing new technologies, and supervising junior lab members.   Responsibilities: - Ensures oversight of the Translational Genomics lab, including directly supervising one scientist. - Contributes expertise to experimental design and conducts translationally focused studies to support drug programs. - Develops and implements RNA and DNA based technologies and establishes QC metrics for the group. - Responsible for the development of assays to be used as potential predictive and pharmacodynamic biomarkers. - Responsible for data analysis, documentation of the work, and clear communication of results in group settings. - Drives technical innovation within the genomics space across multiple platforms, including single cell genomics and GeoMx. - Acts as subject matter expert for clinical application of genomics technologies and analytical tools. - Assists with budgeting, forecasting and project coordination for the lab. - Facilitates working relationships with CROs to outsource or collaborate on technical development efforts.
Job ID
2021-1243
Location
US-MA-Cambridge
As a key member of the Clinical Operations team, this role will work closely with the Vice President of Global Development Operations and will be responsible for leading the activities in the preparation, implementation, and completion of various clinical trials in accordance with the program strategy. This role joins a growing organization and contributes substantially to how the company will operationalize novel immunotherapy oncology trials in the future.  In addition, this is an opportunity to expand one's own knowledge in the scientific and research aspects of immuno-oncology through day-to-day activities and close interactions with the Translational Sciences, Research, and Discovery teams within Jounce.
Job ID
2021-1241
Location
US-MA-Cambridge
Role Description: Jounce Therapeutics is looking a for a Quality Assurance Manager/Sr. Manager to join a highly experienced team dedicated to transform the treatment of cancer. The ideal candidate will have a strong understanding of regulatory requirements and industry standards to support daily GxP activities for clinical stage programs. This role will collaborate with cross functional teams as well as implement and maintain critical quality systems. The QA Manager/Senior Manager will also have the opportunity to work on continuous improvements to build efficient, stage appropriate, and compliant processes.   Responsibilities: - Assist in the development and implementation of the Jounce Quality System (Deviations, CAPA, Change Control, Vendor Selection & Qualification, cGxP Training Program, etc.). - Manage QA Document Control and GxP Employee Training records through collaboration with key stakeholders in identifying phase-appropriate SOPs, and continued development of GxP employee training program. - Represent Quality Assurance in cross-functional meetings and/or projects - Provide QA CMC Operations oversight and support for end to end supply chain coverage. - This includes quality & compliance support of manufacturing, testing, packaging/ labeling and distribution activities by CMOs for Jounce’s drug substance and drug product global operations (i.e., Product Specifications, Batch Records, Deviations, Investigations, Change Control, QA Lot Disposition, Stability, Retest/Expiration Extensions, temperature excursions, Analytical Method Qualification/Validation). - Ensure that Jounce products meet defined quality standards through batch record review and facilitation of product-related investigations.  - Support external vendor audits as needed to include oversight of vendor management program as needed. - Support eQMS implementation and conversion of current QMS to eQMS in a streamlined process to include training of systems - Experience with implementing and maintaining QMS software such as Veeva Quality Docs/QMS - Other QA related job duties as needed with shifting of priorities -   - Oversee the generation, review and/or approval of internal and external documents used in GMP activities such as, but not limited to, master batch records, stability protocols/ reports, specifications, deviations, change controls etc. - Track and monitor QA performance metrics and data to drive continuous improvements of internal processes. Generate and evaluate data to support Key Performance Indicators.
Job ID
2021-1239
Location
US-MA-Cambridge
Reporting to the CSO, the Head of Translational Science will be responsible for the infrastructure, processes, technologies, partnerships, etc. directing Jounce’s discovery and clinical translational efforts at a program and portfolio level to achieve our vision of developing the right immunotherapies for the right patients.   - Lead and mentor a group of experienced scientists engaged in experimental immunology, genomics, bioinformatics, pathology and translational strategy work. - Serve as leader, mentor and subject matter expert bridging ongoing discovery and translational efforts with early clinical development. Guide team members to identify and implement translational activities appropriate for pre-clinical stage target validation. - Provide leadership in the integrative analysis of gene expression, flow cytometry, protein, and drug response data for baseline and post‐dose biomarker discovery for preclinical and clinical programs. Create and champion biomarker strategies within the company, including mentoring team members to author sections of protocols, biomarker reports, and agency submissions. - Discover, develop and implement novel or existing pharmacodynamic and predictive biomarker efforts for first in man immunotherapies as programs transition to development. - Improve internal translational platform by providing strategic and technical leadership for curating and mining of proprietary and public domain datasets to identify novel therapeutic targets. - Collaborate with internal groups to establish and coordinate partnerships and vendor relationships to maximize translational aspects of all pipeline programs. - Interface with the clinical and regulatory teams to most efficiently guide translational and biomarker studies. - Leading a function of 15+, budget for, coordinate, and establish integrated efforts of resources including biologists working with samples from patients in our trials and a genomics/bioinformatics group. Establish work plans so that department members contribute to cross functional pre-clinical and clinical program teams to meet the needs of those programs. - Further establish efforts at Jounce to be recognized as a leader in translational science applied to novel immunotherapy mechanisms, including publications and scientific meeting attendance. 
Job ID
2021-1236
Location
US-MA-Cambridge
The Principal Scientist/ Sr Engineer level position in CMC at Jounce Therapeutics will report to the Sr Director of CMC Operations and will be responsible for managing the outsourced development and manufacturing operations of biologics to contract manufacturers.  Additionally, this position will include laboratory work. Successful execution of this role requires a strong scientific approach and established expertise in therapeutic process development or manufacturing.   The responsibilities include: - Support CMC Operations team with CRO/CMO project management - Assist in planning, writing and reviewing CMC sections across all regulatory submissions in a uniform style and language for regulatory compliance - Reviews ancillary CMC documents and reports for completeness and accuracy and for compliance with regulations - Assist in the timely and accurate assembly of responses to inquiries from regulatory agencies on CMC content of regulatory submissions - Lead or participate in Project and CMC development teams, as required. - Establish effective working relationships within Jounce functions, including Research, Regulatory, Quality Assurance and Legal departments - Execution and documentation of experiments in cell line development, bioreactor operation, or purification of biologics in support of technology and drug development
Job ID
2021-1232
Location
US-MA-Cambridge
We are looking for a highly experienced clinical biomarker professional to pioneer and head up the clinical biomarker/bioanalysis function within Jounce.  This person will be a key contributor to the clinical biomarker plan development, and will be responsible for plan implementation including identification of appropriate vendors/platforms, establishment of assays, and oversight of data generation. They will ensure appropriate data analysis and interpretation to support decision-making and reverse translations for Jounce clinical-stage programs. The successful candidate will be responsible for overseeing the scientist(s) responsible for clinical bioanalysis and immunogenicity assays and supporting the development and implementation of fit-for-purpose or GLP-validated non-clinical assays during the IND-enabling stage. The Assay Head will also contribute to the development of companion diagnostic assays, participate in partner selection, and oversee technical performance to ensure that partnered assays are sufficiently validated to meet the necessary regulatory standards and are performed in accordance with those standards.  Finally, the individual will serve as a resource for discovery-stage research scientists involved with the identification of potential biomarkers and formulation of early biomarker plans.   Responsibilities: - Collaborate cross functionally with nonclinical, translational and clinical functions to create clinical biomarker plans, and then lead implementation of clinical biomarker plans for Jounce clinical-stage programs; - Identify robust assay platforms and vendors suitable for clinical sample analysis; - Develop/transfer assays for clinical biomarkers to appropriate vendors and oversee assay development, fit-for-purpose validation, and report generation; - Oversee the bioanalytical assay scientist(s) and function including assay development, validation and sample testing for generation of pharmacokinetic, toxicokinetic and immunogenicity data at external CROs to support INDs/CTAs and BLAs; - In collaboration with clinical operations, ensure clinical sample collection and analysis proceeds smoothly, confirm the quality of the data generated, and oversee generation of sample analysis reports in accordance with agreed timelines; - Collaborate with the subject matter experts, clinical pharmacology, biostatistics, programming and data management to ensure appropriate data analysis, reporting and interpretation of raw biomarker data, PD and PK/PD analyses; - Participate in corporate budget development with accountability for IND-enabling and clinical biomarker and bioanalytical assay budgets; - Collaborate with discovery, research and translational functions on proactive biomarker planning and generation of IND-enabling non-clinical data for early-stage compounds; - Represent Jounce in companion diagnostic or potential companion diagnostic partnerships to ensure that partnered assay validations meet all relevant regulatory requirements; - Participate in planning and authoring of regulatory and clinical documents, posters and publications; and - Serve as a resource for development of biomarker plans and assays for potential and late-stage discovery and early development candidate-stage programs.  
Job ID
2021-1231
Location
US-MA-Cambridge