Jounce Therapeutics

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Jounce Therapeutics, Inc. is a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long-lasting benefits to patients through a biomarker-driven approach. Jounce currently has multiple development stage programs ongoing while simultaneously advancing additional early-stage assets from its robust discovery engine based on its Translational Science Platform. Jounce’s highest priority program, JTX-8064, is a LILRB2 (ILT4) receptor antagonist shown to reprogram immune-suppressive tumor associated macrophages to an anti-tumor state in preclinical studies. A Phase 1 clinical trial, named INNATE, for JTX-8064 as a monotherapy and in combination with JTX-4014, Jounce’s internal PD-1 inhibitor, or pembrolizumab is currently enrolling patients with advanced solid tumors. Jounce’s most advanced product candidate, vopratelimab, is a monoclonal antibody that binds to and activates ICOS, and is currently being studied in the SELECT Phase 2 trial. JTX-4014 is a PD-1 inhibitor intended for combination use in the INNATE and SELECT trials and with Jounce’s broader pipeline. Additionally, Jounce exclusively licensed worldwide rights to JTX-1811, a monoclonal antibody targeting CCR8 and designed to selectively deplete T regulatory cells in the tumor microenvironment, to Gilead Sciences, Inc. All applicants should be legally entitled to work for any employer in the U.S.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

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The Discovery team at Jounce is hiring! We are seeking an Associate Scientist/ Senior Associate Scientist specializing in in vitro biology to join our Discovery Immuno-Oncology team. The successful candidate will be an experienced and highly motivated laboratory researcher engaged in the discovery and testing of novel cancer immunotherapeutic biologics. They will generate data to identify and support advancement of new projects into the Discovery pipeline and will be expected to participate in decision-making by sharing their expertise and perspective. Responsibilities include designing, developing, and conducting experiments aimed at identifying candidates for antibody therapeutics. They will have the opportunity to work independently and collaboratively to discover and advance new programs in a dynamic and fast-paced environment.    Responsibilities   - Development and troubleshooting of immune cell-based assays using human primary cells and cell lines to validate the immunomodulatory activity of candidate therapeutics;  - Investigation of the biological effects of target engagement, by either antibody or gene targeting approaches, utilizing a variety of techniques including immunophenotyping by multi-color flow cytometry, ELISA and multiplex technologies for measuring secreted cytokines;  - Data analysis, interpretation and thorough documentation of all experiments in the company’s ELN system;  - They will also be responsible for clear communication of results withing the Discovery team and across different departments within the Company;  - Active participation in discussions, data interpretation and troubleshooting across Discovery teams;  - Working cross-functionally as part of internal multi-disciplinary project teams; and  - Maintaining a safe and clean laboratory environment following all precautions for working in a BSL2/BSL2+ laboratory.   
Job ID
2022-1289
Location
US-MA-Cambridge
The Human Resources department at Jounce is hiring! We are seeking an Associate Director/Director of Human Resources to lead our employee experience and serve as an HR Business Partner to our Product Development and Technical Operations (PDTO) organization as well as several G&A departments.  This is an exciting opportunity to contribute as a key functional HR leader, and to work directly with key business units to advance their priorities.  This is a great opportunity for those who enjoy a mix of strategic and hands-on work focused on finding and driving solutions to complex business challenges.     Responsibilities    - Drive positive and effective employee experience processes from onboarding through exit, including areas such as immigration and employee learning and development;  - Support PDTO and several G&A departments as their HR Business Partner – identifying and executing HR programs and initiatives in support of business unit plans;  - Assesses organizational effectiveness from multiple views of impact and develop solutions to support business improvements;  - Oversee and supervise HRIS (ADP) and other HR workflows, continuously assessing opportunities to leverage technology to streamline and improve processes, workflows, and reporting across the HR function and with Finance, Legal, and IT;  - Provide high level coaching and counsel to leaders and partner with department leaders and leadership teams to ensure the overall organization and culture are designed around company goals and objectives; and  - Partner effectively with other HR leaders as both a service provider and customer.  
Job ID
2022-1288
Location
US-MA-Cambridge
The Manager, Clinical Data Management will be responsible for lead data management responsibilities for oversight of concurrent clinical trials, utilizing electronic data capture and management systems in an outsourced model.  The selected candidate will manage trials in various stages, including planning, start-up, conduct, closeout, and archiving.  The position encompasses complex clinical data management projects and is responsible for routine clinical data management tasks to collect, code, process, review, and validate clinical trial data received in-house and remotely. The candidate will maintain a high level of data quality by creating and adhering to standard eCRFs and data structures and corresponding standard edit checks and review listings.  The selected candidate will assist in the design and implementation of clinical data management processes with selected service providers , ensuring completeness, correctness, and consistency according to the Jounce standards in order to ensure complete, accurate, high quality, regulatory compliant data in support of publications and regulatory submissions. This individual will be a core member of the Clinical Study Team(s)and will collaborate with the Biostatistics, Statistical Programming and Clinical Operations team members, and other functions as applicable.       Responsibilities:  - Leadership and oversight of eCRF development (by service provider) and facilitation of cross-functional reviews of eCRF content; direct database building activities, including review of edit check specifications and performance of user acceptance testing for assigned projects;  - Monitor data collection, coding, and cleaning by CROs and service providers through tracking of study metrics and targeted data reviews;  - Study level coordination and hands on review of Data Management Plans, CRF completion guidelines, edit check specifications, external data transfer specifications and other study documentation prepared internally or by service providers;  - Support the development and implementation of standard CDM workflows and infrastructure strategy (such as preferred provider interactions, Jounce standard CRFs, SOPs, and templates) that reflects data collection standards, consistent with industry best practice;  - Represent data management and effectively communicate requirements, timelines and deliverables at internal cross-functional team meetings and meetings with service providers;  - Provide input on the review clinical protocols/amendments, clinical study reports, statistical analysis plans, etc.;  - Develop and maintain productive business relationships with internal and external partners, including Biostatistics, Statistical Programming, Clinical Operations, Medical, Quality Assurance, Drug Safety and Pharmacovigilance, and Regulatory Affairs; CROs, central and local laboratories, and other vendors;  - Ensure completeness, correctness and consistency of clinical data and data structure across projects; and  - Provide guidance and training to CROs, vendors, investigators, and study coordinators on study requirements as applicable. 
Job ID
2022-1287
Location
US-MA-Cambridge
We are seeking a highly motivated, solutions oriented Executive Assistant to cross-functionally support the Chief Scientific Officer and Research Leadership Team (RLT) at Jounce Therapeutics.  The successful candidate will play an integral role in the day to day operations of the Research function and will also be profoundly impactful as a key member of the Jounce Administrative Team.  In this role, the ideal candidate will provide high level executive support including diverse calendar management and assisting the CSO in department operations in a fast-paced environment with quickly evolving priorities.  We are looking to expand our energetic, proactive, and autonomous group by adding a dynamic EA to our Administrative Team!     Responsibilities:  - Calendar Management for the Research Organization including the CSO, the Senior Director of Discovery, the Senior Director of In Vivo and Ex Vivo Sciences, and the Senior Director of Translational Sciences. Responsibilities include scheduling, appointments, and prioritizing real-time changes. Must be able to independently identify and resolve issues within calendars/schedules;  - Contribute to planning and organization of Board of Directors Science and Technology Committee meetings including the creation and distribution of board materials for Research and working closely with the CSO, RLT and EA colleagues;  - Ownership and coordination of RLT meetings including project management, scheduling, document compilation, collecting meeting minutes and general meeting administration;  - Meeting and Event Preparation; including set up and follow up, as well as presentation proofing and edits. This role will be responsible for preparing necessary meeting materials;  - Word processing such as formatting templates, documents, and PowerPoint presentations. Expertise in PowerPoint is particularly valuable including building and editing slide decks.  - Contribute to and participate in the goals and projects of the Jounce Administrative Team;  - Prepare expense reports and reconcile company credit cards;  - Organize domestic and international travel;  - Provide general department-wide administrative support and coordination to the Research Function including but not limited to general budget and conference tracking, Research-wide meetings, lab scheduling processes, etc; and   - Provide basic administrative support (i.e. expense reports, calendaring) for smaller G&A groups, such as Human Resources. 
Job ID
2022-1286
Location
US-MA-Cambridge
The Medical Affairs at Jounce is hiring! We are seeking a Medical Science Liaison. Jounce has had a strong Medical Science Liaison (MSL) team to support our advancing clinical and research programs since 2019.  The MSL position is an exciting opportunity to join a company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and may bring long lasting benefits to patients. The MSLs are highly trained Medical Affairs (MA) professionals with strong clinical and/or scientific backgrounds.     We expect MSLs to have excellent communication and presentation skills. MSLs should demonstrate a solid understanding of immuno-oncology as a therapeutic disease area as well as knowledge of clinical trial sites and/or connections with oncology experts. The Medical Science Liaison functions as a field-based, scientific expert who engages health care professionals to exchange clinical, scientific, and research knowledge. By following regulatory and corporate guidelines, they will facilitate and build scientific relationships and collaborations with the medical/scientific community as well as support clinical study initiatives (including patient enrollment in clinical trials). This position interacts with local, regional, and national HCPs; societies; and organizations. Due to the early stage of development of multiple compounds, the MSL will be utilized heavily in supporting clinical operations and clinical development.    In addition to a world-class research organization, Jounce prides itself on a solid translational and reverse translation approach to clinical trials.  Currently (though that may change in the future), the focus is mostly on early clinical development (phase 1 and 2).  MSLs will need to have a solid understanding of translational approaches within clinical studies while interacting with key clinical experts in the field.    Responsibilities (will include but are not limited to the following):  - Function as the primary point of contact in the field for Jounce Medical Affairs;  - Maintain clinical, scientific, and technical expertise in relevant Immuno-Oncology/Oncology disease state areas;  - Have a thorough understanding of Jounce clinical protocols and related procedures;  - Collaborate with clinical operations and clinical development to support the recruitment of clinical trials, identify potential new clinical trial sites, and serve as an on-site Jounce resource to study site staff participating in Jounce studies;  - Execute study enrollment plans and clinical trial site engagement activities;  - Develop and track key opinion leader (KOL) engagement plans - identify, develop, and maintain long-term collaborative relationships with KOLs within assigned region. Participate in medical & scientific exchanges with the medical/scientific community including advisory boards;  - Respond to and document unsolicited requests for information on Jounce clinical programs;  - Facilitate company sponsored trials and serve as a resource for investigator sponsored trial (IST) proposals. Provide medical/clinical teams with feedback and insights from interactions with KOLs and investigators;  - Facilitate research collaborations with key investigators including helping identify, establish, and maintain such collaborations;  - Represent the company at medical meetings through Medical Affairs’ Scientific Booth coverage and other related activities;  - Adhere to corporate SOPs and ensure vigilant compliance with relevant legal and regulatory guidelines governing scientific interactions with physicians and healthcare professionals across all activities, including those related to clinical trials, scientific interactions with internal and external groups, and responses to unsolicited requests for medical/scientific information;  - Consistently demonstrate a high standard of excellence in the management of assigned territory while also contributing to the success of colleagues and the MSL organization; and  - MSLs must contribute to the achievement of organizational goals beyond the borders of a geographic territory.
Job ID
2022-1285
Location
US-
The Medical Affairs at Jounce is hiring! We are seeking a Medical Science Liaison. Jounce has had a strong Medical Science Liaison (MSL) team to support our advancing clinical and research programs since 2019.  The MSL position is an exciting opportunity to join a company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and may bring long lasting benefits to patients. The MSLs are highly trained Medical Affairs (MA) professionals with strong clinical and/or scientific backgrounds.     We expect MSLs to have excellent communication and presentation skills. MSLs should demonstrate a solid understanding of immuno-oncology as a therapeutic disease area as well as knowledge of clinical trial sites and/or connections with oncology experts. The Medical Science Liaison functions as a field-based, scientific expert who engages health care professionals to exchange clinical, scientific, and research knowledge. By following regulatory and corporate guidelines, they will facilitate and build scientific relationships and collaborations with the medical/scientific community as well as support clinical study initiatives (including patient enrollment in clinical trials). This position interacts with local, regional, and national HCPs; societies; and organizations. Due to the early stage of development of multiple compounds, the MSL will be utilized heavily in supporting clinical operations and clinical development.    In addition to a world-class research organization, Jounce prides itself on a solid translational and reverse translation approach to clinical trials.  Currently (though that may change in the future), the focus is mostly on early clinical development (phase 1 and 2).  MSLs will need to have a solid understanding of translational approaches within clinical studies while interacting with key clinical experts in the field.    Responsibilities (will include but are not limited to the following):  - Function as the primary point of contact in the field for Jounce Medical Affairs;  - Maintain clinical, scientific, and technical expertise in relevant Immuno-Oncology/Oncology disease state areas;  - Have a thorough understanding of Jounce clinical protocols and related procedures;  - Collaborate with clinical operations and clinical development to support the recruitment of clinical trials, identify potential new clinical trial sites, and serve as an on-site Jounce resource to study site staff participating in Jounce studies;  - Execute study enrollment plans and clinical trial site engagement activities;  - Develop and track key opinion leader (KOL) engagement plans - identify, develop, and maintain long-term collaborative relationships with KOLs within assigned region. Participate in medical & scientific exchanges with the medical/scientific community including advisory boards;  - Respond to and document unsolicited requests for information on Jounce clinical programs;  - Facilitate company sponsored trials and serve as a resource for investigator sponsored trial (IST) proposals. Provide medical/clinical teams with feedback and insights from interactions with KOLs and investigators;  - Facilitate research collaborations with key investigators including helping identify, establish, and maintain such collaborations;  - Represent the company at medical meetings through Medical Affairs’ Scientific Booth coverage and other related activities;  - Adhere to corporate SOPs and ensure vigilant compliance with relevant legal and regulatory guidelines governing scientific interactions with physicians and healthcare professionals across all activities, including those related to clinical trials, scientific interactions with internal and external groups, and responses to unsolicited requests for medical/scientific information;  - Consistently demonstrate a high standard of excellence in the management of assigned territory while also contributing to the success of colleagues and the MSL organization; and  - MSLs must contribute to the achievement of organizational goals beyond the borders of a geographic territory.
Job ID
2021-1284
Location
US-
We are seeking an experienced program manager for Jounce immunotherapy programs. The ideal candidate will have a strong scientific background with experience developing biologics, preferably in oncology. In collaboration with the Program Leader, you will work with Jounce’s cross-functional teams, including research and clinical, to drive scientific ideas derived from our groundbreaking translational science platform into new medicines to treat serious unmet medical needs. This role reports to the Senior Vice President, Program and Portfolio Strategy.    Responsibilities:   - Proactively define (with cross-functional team) program strategy, goals, decision points, investments and areas of risk and associated mitigations on development and research-based programs;  - Ensure roles and responsibilities are well-understood within the program teams to maximize forward progress on the program while maintaining alignment between and across functions;  - Drive execution of program plan while providing visibility to progress versus timeline & changes to risk profile; communicate program status and issues to key stakeholders and senior management;  - Facilitate collaborative decision-making discussions with senior leaders and alliance partners;  - Establish and maintain detailed integrated program plans with input from all functions; engage in robust scenario planning for evaluation of alternatives;  - Maintain visibility and operational oversight of resource planning and cost vs budget;  - Facilitate establishment of program goals and track their execution to deliver on overall corporate goals;  - Lead efforts to further develop the program management function and new initiatives in accordance with the needs of the business; and  - Encourage and demonstrate true Jounce spirit of collaboration and fun throughout the organization. 
Job ID
2021-1281
Location
US-MA-Cambridge
The Biostatistics and Programming team at Jounce Therapeutics is hiring! We are seeking a VP level leader who will be responsible for managing a group of statisticians and programmers to support all statistical and programming needs for Jounce programs from pre-IND through BLA.  As a member of the Clinical Development and Regulatory Affairs Leadership Team, the ideal candidate will play a key role in strategic planning for all Jounce clinical programs.     Responsibilities:  - Provide strategic and statistical expertise in design of clinical development plans, clinical study protocols, analysis, and clinical study reports for phase 1 trials through BLA;  - Functional Representative in key internal facing senior meetings such as program teams, clinical development and regulatory affairs leadership team, portfolio steering team and management team, as well as more external facing meetings such as Board of Directors;  - Summarize and present statistical strategies and/or key study results to internal governance bodies, external collaborators including business partners and regulatory agencies;  - Plan and oversee deliverables and timeline of study readouts including regular data reviews, predefined interim analysis and final analysis to support decision making;  - Work closely with clinical development, clinical operations, pharmacovigilance, clinical pharmacology, translational science, and medical writing to support clinical study planning and execution;  - Manage an existing team of statisticians and statistical programmers and support and foster their professional development needs and build the team as Jounce programs progress towards BLAs.;  - Represent Biostatistics function in the program team and contribute to cross-functional decision making on study design, endpoint selection, data collection, and analysis strategies, ensuring alignment with study objectives;  - Perform sample size calculation for continuous, dichotomous, and time to event endpoints in various study design;  - Perform simulation studies to explore the statistical operating characteristics in study design phase including innovative/adaptive designs;  - Proactively identify and anticipate technical or data related issues arising in the design, conduct or analysis of clinical trials or other scientific research, and approve and implement alternative analysis strategies or other recommendations to address these issues;  - Evaluate performance of patient enrichment biomarkers including metrics for AUC, PPV, NPV and determination of assay thresholds for use in prospective trials;  - Write the statistical section in clinical protocols;  - Develop statistical analysis plans, coordinate and perform data analysis and validation as necessary, and provide data interpretation;  - Develop exploratory statistical analysis plans for predictive and pharmacodynamic biomarkers and help develop companion diagnostics strategies for the program;  - Interpret study results and write (or at least QC and review) statistical summary reports of study results;  - Perform statistical analyses to support publications in medical conferences;  - Collaborate with Jounce data management team to support QC of CRO activities to include UAT, Query management, Data review, DM documentation such as DMP, DVS, edit checks, coding, lock process;   - Support development of eCRFs and be responsible for specs for IVRS, SDTM, and ADaM;  - Contribute to the implementation, maintenance, and evolution of the systems and processes involved in the collection, review and analysis of clinical and translational data;  - Responsible for statistical programming activities including the development of standard statistical documents such as TLFs, Programming specs (e.g. SDTM and ADaM), SAS macros, and SOPs; and  - Develop proper resources and process regarding hardware, software, SOP and work instructions to provide effective support to clinical studies, and ascertain needs for potential program development of novel statistical methodology. 
Job ID
2021-1280
Location
US-MA-Cambridge
The Clinical Operations team at Jounce is hiring! We are looking for a motivated, early career CTA who will assist with daily clinical trial execution activities. The successful candidate will also work with senior staff in the coordination of documentation associated with the conduct of investigational clinical studies in accordance with Food and Drug Administration (FDA) Regulations, Good Clinical Practice (GCP), and company standard operating policies and procedures. This is a great growth opportunity within a well-established clinical team.     Responsibilities:   - Contribute to and support the Clinical Operations team by executing clinical trial components up to set quality standards;  -  Oversight of study Enrollment Authorization Forms including review and edits;  - Responsible for study laboratory sample management, including tracking and vendor management support;  - Ownership of trial information data flow, including collection and dissemination to the internal project team, CROs, and other stakeholders;  - Schedule and coordinate study meetings, materials and agendas; recording and disseminating decisions and actions;  - Responsible for quality control of the eTMF including maintenance and oversight;  - Coordinate and manage version control of clinical document;  - Prepare distribution of copies of finalized protocol and study documents;  - Draft and coordinate the ICF review;  - Assist in development and monitor compliance of study plans, including Lab Manual, Clinical Monitoring Plan, Study Plan, Study Vendor Oversight Plan, Pharmacy Manual, and others;  - Assist in responding to Data Correction Forms (DCFs) and track DCF follow-up and completion activities;  - Assist in the coordination and tracking of clinical supply shipments, including review and approval of Regulatory Documentation Packages;  - Assist in the creation and updating of standardized clinical trial tools, processes, and SOPs; and  - Organize and maintain tracking systems and tools to support the conduct of a clinical study from start-up to close-out. 
Job ID
2021-1279
Location
US-MA-Cambridge
The Protein Analytics and Analytical Development group at Jounce Therapeutics is looking for an individual with expertise in antibody therapeutics, especially in the fields of antibody characterization/developability assessment and analytical method development.   This is an exciting opportunity to play an important role in the discovery and development of novel biotherapeutics in immuno-oncology.  The successful candidate will lead experimental design, interpret analytical data, optimize throughput, maintain detailed records, develop new technology, generate standard operating procedures and reports, and present results to cross-functional teams.  In this role you will have the opportunity to work cross functionally across multiple departments including discovery/biology, Ab technology, protein production, and CMC. Additionally, you will be using the latest protein analytical tools to ultimately impact the development of biotherapeutics.     Responsibilities:   - Develop, optimize and execute characterization assays for biotherapeutics;  - Evaluate and implement new analytical approaches to improve the quality and efficiency of analytical development work and to solve problems encountered during drug candidate selection and development;  - Provide analytical testing support to enable drug candidate selection, development and reagent generation;  - Monitor and maintain instruments regularly to ensure proper operation and calibration;   - Maintain excellent documentation in the form of electronic lab notebook (ELN) and reports;  - Proactively share skills/knowledge with others to broaden company capabilities; and  - Participate in cross-functional teams through data sharing and discussion. 
Job ID
2021-1278
Location
US-MA-Cambridge
The Protein Production Group at Jounce Therapeutics is hiring! We are seeking a scientist experienced in mammalian cell culture, protein purification, and characterization. The successful candidate will play an important role in the discovery and development of novel biotherapeutics for immuno-oncology.  The successful candidate will be responsible for the production and purification of antibodies and other proteins for use in R&D that will enable the development of groundbreaking therapies. The successful candidate will be expected to participate in experimental design, conduct experiments, optimize throughput, maintain detailed records, and participate in cross-functional collaborations.  This is an exciting opportunity to be part of a collaborative and fun team within the fast-paced and dynamic field of immuno-oncology.    Responsibilities  - Perform transient protein production in mammalian cell lines;  - Conduct protein purification steps including affinity chromatography, ion-exchange chromatography and size-exclusion chromatography;  - Perform protein characterization methods including SE-HPLC, SDS-PAGE, endotoxin assays and western blots;  - Employ liquid handling robots in the protein production process at smaller scales;  - Utilize automated platforms to generate transfection-grade plasmid DNA; and  - Ensure thorough documentation and cross-functional communication. 
Job ID
2021-1276
Location
US-MA-Cambridge
We are looking for a highly motivated scientist to join the Discovery Immuno-Oncology group at Jounce Therapeutics. The successful candidate for this position will play a leading role within a team of scientists engaged in the discovery and validation of novel cancer immunotherapeutic targets. Responsibilities include designing, developing, and conducting experiments aimed at identifying novel oncology targets amenable to biologic therapies, and demonstrating immunomodulatory activity supportive of entry into the Jounce Discovery pipeline. The candidate must be capable of working across functional groups and communicating results with scientists from diverse backgrounds. The ideal candidate should be a highly motivated self-starter capable of working independently and as part of a team.     Responsibilities   - Lead the design and execution of immune cell-based experiments, using both primary cells and cell lines, to identify and validate novel oncology biologics targets;  - Independently work to generate, critically analyze and interpret data with scientific rigor and an open mind; - Work collaboratively with scientists and research associates within and across teams to accomplish program goals and drive key decisions; - Provide both Immuno-Oncology guidance and technical expertise to a cross-functional team; and  - Thorough documentation of experiments in the company’s ELN system and communication of results across functional teams. 
Job ID
2021-1275
Location
US-MA-Cambridge
We are inviting an engaged and proficient Research Technologist to contribute to the development of novel therapeutics in the field of cancer immunotherapy by joining Jounce`s Translational Pathology Team. The successful applicant will assist in managing translational pathology assessments of pre-clinical and clinical samples and will contribute to biomarker discovery and application efforts to advance our drug discovery pipeline. This is a full-time position based in Cambridge and a great opportunity to bepart of a dedicated multi-disciplinary team   Responsibilities  - Pre-analytical processing and sectioning of specimens, immunohistochemical and immunofluorescence staining with automated staining systems, experimental design, assay optimization and troubleshooting;  - Generation and analysis of whole slide digital images with state-of-the-art software modules;  - Contribute to exploration and implementation of novel imaging/molecular biology technologies and approaches for evaluation of predictive and pharmacodynamic biomarkers in human tissues; and  - Active membership of scientific project teams providing pathology subject matter expertise. 
Job ID
2021-1274
Location
US-MA-Cambridge
Jounce is looking for an Associate Scientist/ Senior Associate Scientist specializing in in vitro biology to join our Discovery Immuno-Oncology Team. The successful candidate will be an experienced and highly motivated laboratory researcher engaged in the discovery and testing of novel cancer immunotherapeutic biologics.  They will generate data to support key decisions for project teams and will also participate in the decision-making by sharing their expertise and perspective. Responsibilities include designing, developing, and conducting experiments aimed at identifying optimal therapeutic candidates and understanding the mechanism of action of our therapeutic molecules (mostly monoclonal antibodies). They will have the opportunity to work independently and collaboratively to advance portfolio programs in a dynamic and fast-paced environment.    Responsibilities   - Development and troubleshooting of immune cell-based assays using human primary cells and cell lines to validate the immunomodulatory activity of candidate therapeutics and performance of screening assays for therapeutic lead selection;  - Investigate the biological effects of our molecules utilizing a variety of techniques including immunophenotyping by multi-color flow cytometry, intracellular cytokine staining, ELISA and multiplex technologies, proliferation assays and primary immune cell isolation;  - Active participation in discussions, and troubleshooting, of data across the Discovery team;  - Thorough documentation of work including data analysis and interpretation and keeping records of experiments in the Company’s eLN system. They will also be responsible for clear communication of results within the Discovery team and also across different departments within the Company;  - Working cross-functionally as part of internal multi-disciplinary project teams; and   - Maintaining a safe and clean laboratory environment following all precautions for working in a BSL2/BSL2+ laboratory. 
Job ID
2021-1272
Location
US-MA-Cambridge
Jounce is looking for a Research Associate/Senior Research Associate Scientist specializing in in vitro biology to join our Discovery Immuno-Oncology Team. The successful candidate will be a highly motivated bench scientist committed to elucidating the mechanism of action, and enabling the development, of novel cancer immunotherapeutic biologics. They will generate data to support key decisions for project teams and actively participate in the interpretation of data and design of experiments. They will have the opportunity to work independently and collaboratively to advance portfolio programs in a dynamic and fast-paced environment.    Responsibilities  - Performance of immune cell-based in vitro assays, including primary immune cell isolation, mammalian cell culture, multi-color flow cytometry, ELISA, multiplex technologies and proliferation assays;  - Data analysis and thorough documentation of work in the Company’s eLN system;  - Presentation of results in team meetings and other group settings;  - Working cross-functionally as part of internal multi-disciplinary project teams; and  - Maintaining a safe and clean laboratory environment following all precautions required for a BSL2/BSL2+ setting. 
Job ID
2021-1270
Location
US-MA-Cambridge
We are looking for a highly motivated scientist to join the Discovery Immuno-Oncology Group at Jounce Therapeutics. The successful candidate for this position will play a leading role within a team of scientists engaged in the discovery and testing of novel cancer immunotherapeutic biologics. Responsibilities include designing, developing, and conducting experiments aimed at identifying optimal immunotherapeutic biologics, understanding their mechanism of action, and playing a key team role in supporting a program from discovery to development. The candidate must be capable of working across functional groups and communicating results with scientists from diverse backgrounds. The ideal candidate should be a highly motivated self-starter capable of working independently and as part of a team.     Responsibilities  - Lead the design and execution of immune cell-based experiments, using both primary cells and cell lines, to characterize the mechanism of action of therapeutic candidates;  - Independently work to generate, critically analyze and interpret data with scientific rigor and an open mind;  - Work collaboratively with scientists and research associates to accomplish program goals and drive key decisions;  - Provide both immuno-oncology guidance and technical expertise to a cross-functional team; and  - Thorough documentation of experiments in the Company’s eLN system and communication of results across functional teams. 
Job ID
2021-1269
Location
US-MA-Cambridge
The Quality Assurance Team Jounce is hiring! We are seeking a Senior Specialist/ Manager, QA to join a highly experienced team dedicated to transforming the treatment of cancer. The ideal candidate will have a strong understanding of regulatory requirements and industry standards to support daily cGxP activities for clinical stage programs. This position will develop and maintain the Quality Management System (QMS) and provide Quality Oversight. The QA Manager initiates and implements quality improvement activities as appropriate to raise performance of the company systems and services; additionally, they guide and mentor designated representatives and they train company employees regarding their impact on the process streamlining, improvements, and QMS.    Responsibilities   - Lead QA Document Control and GxP Employee Training records through collaboration with key stakeholders in identifying phase-appropriate SOPs, and continued development of GxP employee training program;  - Provide professional expertise and guidance on Good Clinical Practice (GCP) and applicable regulations to clinical development teams to proactively identify compliance issues/risks and recommend mitigation;  - Support the implementation of Jounce eQMS to include EDMS/Training to include training of systems in phase appropriate manner;  - Author, review or revise QMS relevant controlled documents;  - Support QMS alignment with other company programs and management system;  - Coordinate and facilitate QMS internal and external audits as applicable;  - Develop and facilitate QMS training plan;  - Manage the Quality Management System (QMS) Corrective Actions process (CAPA) and confirm the effectiveness;  - Develop, implement, maintain, and improve business unit wide quality assurance systems, including tools, policies, training and processes;  - Lead problem solving team and participate in continuous improvement initiatives;  - Manages quality data for accuracy and report generation;  - Other QA related job duties as needed with shifting of priorities; and  - Minimum of Bachelor's degree in science (e.g., biology, chemistry, pharmacy, medical, engineering or related field). 
Job ID
2021-1244
Location
US-MA-Cambridge