Jounce Therapeutics

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Jounce Therapeutics, Inc. is a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and aiming to provide long-lasting benefits to patients through a biomarker-driven approach. Jounce currently has multiple development stage programs ongoing while simultaneously advancing additional early-stage assets from its robust discovery engine based on its Translational Science Platform. Jounce’s highest priority program, JTX-8064, is a LILRB2 (ILT4) receptor antagonist shown to reprogram immune-suppressive tumor associated macrophages to an anti-tumor state in preclinical studies. A Phase 1 clinical trial, named INNATE, for JTX-8064 as a monotherapy and in combination with JTX-4014, Jounce’s internal PD-1 inhibitor, or pembrolizumab is currently enrolling patients with advanced solid tumors. Jounce’s most advanced product candidate, vopratelimab, is a monoclonal antibody that binds to and activates ICOS, and is currently being studied in the SELECT Phase 2 trial. JTX-4014 is a PD-1 inhibitor intended for combination use in the INNATE and SELECT trials and with Jounce’s broader pipeline. Additionally, Jounce exclusively licensed worldwide rights to JTX-1811, a monoclonal antibody targeting CCR8 and designed to selectively deplete T regulatory cells in the tumor microenvironment, to Gilead Sciences, Inc. All applicants should be legally entitled to work for any employer in the U.S.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

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We are seeking an experienced Computational Biologist/Bioinformatician to contribute to the Translational Genomics team at Jounce. We are looking for someone with superior technical skills who can help us use data-driven approaches to advance our programs and inform biomarker strategy. This person will lead the biomarker strategy efforts on an early stage clinical development program as well as contribute to preclinical discovery efforts.  Responsibilities include implementation and maintenance of next generation sequencing (NGS) pipelines and working with teams to design experiments to interrogate immune oncology pathways. The person in this position will work closely with both bioinformatics analysts and wet lab scientists to increase team capabilities and efficiency. The ideal candidate will also act as a partner with the Research Informatics team to help build new tools and build out cloud-based bioinformatics high performance computing capabilities.  Experience with clinical biomarkers is a plus.    Responsibilities:   - Lead program-specific translational genomics strategy and participate in research team meetings, proactively suggest new ways to impact programs from discovery through the clinic; - Develop novel algorithms and implement, validate, and maintain shared pipelines for processing of NGS data (targeted/whole exome, RNA, single cell, TCR, and/or BCR sequencing) and downstream analyses (e.g. TMB, HLA typing, MSI status determination, differential transcript expression); - Evaluate and implement pipeline algorithms based on statistical quality and performance metrics on real and simulated data sets in order to keep our portfolio of tools cutting edge; - Manage existing high-dimensional data resources and ingest new public and internal data sets for use by team members; and - Use best practices for reproducible research and data stewardship.
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The Protein Analytical group at Jounce Therapeutics is looking for an individual with expertise in antibody and protein therapeutics, especially in the fields of protein characterization/developability assessment. In this role you will oversee a small team within the Protein Analytics group and play a leading role in characterizing and developing drug candidates in pre-clinical and clinical stages. This role will be responsible for managing internal resources across multiple programs and providing strategy through the drug development pipeline. The successful candidate will have strong protein biochemistry and biotherapeutic discovery knowledge, be proficient at designing and executing lab experiments, and have demonstrated the ability to lead and manage a small group of scientists. In this role you will have the opportunity to work cross functionally across multiple departments including discovery/biology, Ab technology, protein production and CMC. You will spend approximately 25% of your time in the lab, both conducting your own experiments and mentoring other scientists.  This is an exciting opportunity to play an important role in the discovery and development of novel biotherapeutics for immuno-oncology.    Responsibilities:   - Be thegroup leadfor protein characterization/developability assessment on early stage programs;  - Provide strategic insights for departmental resource planning and the drug development pipeline;  - Managea small group within Protein Analytics focused on supporting the early stage programs;  - Mentor direct reports and other scientists within the group;  - Independently lead and develop new experiments, technological or scientific processes;  - Organize and lead projects in the group to support early discovery and candidate nomination;  - Take a leadership role within the lab and the company; and  - Both prepare and oversee the writing of SOPs and reports. 
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