Jounce Therapeutics

Research Associate/Senior Research Associate, Protein Production Group

Job ID
2021-1251
Category
Research & Development
Job Location
US-MA-Cambridge

Role / Responsibilities

The Protein Production Group at Jounce Therapeutics is looking for an individual experienced in mammalian cell culture, protein purification, and characterization. The successful candidate will play an important role in the discovery and development of novel biotherapeutics for immuno-oncology.  He/she will be responsible for the production and purification of antibodies and other proteins for use in R&D that will enable the development of groundbreaking therapies. He/she will be expected to participate in experimental design, conduct experiments, optimize throughput, maintain detailed records, and participate in cross-functional collaborations.  This is an exciting opportunity to be part of a collaberative and fun team within the fast-paced and dynamic field of immuno-oncology.

 

Responsibilities:

  • Transient protein production in mammalian cell lines
  • Protein purification including affinity chromatography, ion-exchange chromatography and size-exclusion chromatography
  • Protein characterization methods including SE-HPLC, SDS-PAGE, and endotoxin assay
  • Employing liquid handling robots in the protein production process at smaller scales
  • Utilizing automated platforms to generate transfection-grade plasmid DNA
  • Thorough documentation and cross-functional communication

Qualifications

  • BS in biochemistry, bioengineering, chemical engineering or a related discipline with biotech/pharma industry experience preferred
  • Experience with mammalian cell culture and aseptic techniques
  • Ability to operate AKTA purification systems for protein purification (affinity, IEX, SEC)
  • Experience with analyzing proteins (SE-HPLC, endotoxin assays, SDS-PAGE)
  • Excellent attention to detail, strong documentation skills, drive to work in a fast-paced environment, and ability to communicate effectively (both written and verbal)
  • Experience with bacterial culture and plasmid purification is a plus
  • Ablility to utilize liquid handling robots for high-throughput cell culture expression and protein purification techniques is a plus

Statement

Jounce Therapeutics is an equal opportunity employer and does not discriminate in its employment decisions on the basis of race, color, national origin, age, physical or mental disability, marital status, religion, creed, sex, or political beliefs.  We offer a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the U.S. 

Company Summary

Jounce Therapeutics, Inc. is a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long-lasting benefits to patients through a biomarker-driven approach. Jounce currently has multiple development stage programs ongoing while simultaneously advancing additional early-stage assets from its robust discovery engine based on its Translational Science Platform. Jounce’s highest priority program, JTX-8064, is a LILRB2 (ILT4) receptor antagonist shown to reprogram immune-suppressive tumor associated macrophages to an anti-tumor state in preclinical studies. A Phase 1 clinical trial, named INNATE, for JTX-8064 as a monotherapy and in combination with JTX-4014, Jounce’s internal PD-1 inhibitor, or pembrolizumab is currently enrolling patients with advanced solid tumors. Jounce’s most advanced product candidate, vopratelimab, is a monoclonal antibody that binds to and activates ICOS, and is currently being studied in the SELECT Phase 2 trial. JTX-4014 is a PD-1 inhibitor intended for combination use in the INNATE and SELECT trials and with Jounce’s broader pipeline. Additionally, Jounce exclusively licensed worldwide rights to JTX-1811, a monoclonal antibody targeting CCR8 and designed to selectively deplete T regulatory cells in the tumor microenvironment, to Gilead Sciences, Inc. For more information, please visit www.jouncetx.com.

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