Jounce Therapeutics

Associate Scientist / Senior Associate Scientist, Discovery

Job ID
2021-1247
Category
Research & Development
Job Location
US-MA-Cambridge

Role / Responsibilities

Jounce is looking for an experienced Associate Scientist/ Senior Associate Scientist specializing in In Vitro biology to join our Discovery Immuno-Oncology team. The successful candidate will be an experienced and highly motivated laboratory researcher engaged in the discovery and testing of novel cancer immunotherapeutic biologics. S/he will generate data to support key decisions for project teams and will also participate in the decision-making by sharing her/his expertise and perspective. Responsibilities include designing, developing, and conducting experiments aimed at identifying optimal therapeutic candidates and understanding the mechanism of action of our therapeutic molecules (mostly monoclonal antibodies). S/he will have the opportunity to work independently and collaboratively to advance portfolio programs in a dynamic and fast-paced environment.

 

Responsibilities:

  • Perform various in vitro immune cell culture assays, immunophenotyping by multi-color flow cytometry, intracellular cytokine staining, ELISA and multiplex technologies, proliferation assays and primary immune cell isolation
  • Perform screening assays for therapeutic lead selection
  • S/he will be responsible for data analysis, thorough documentation of work, and clear communication of results in group settings
  • Work cross-functionally as part of internal multi-disciplinary project teams
  • Maintain a safe and clean laboratory environment following all precautions for working in a BSL2/BSL2+ laboratory.

Qualifications

  • Degree in immunology, cancer biology, cell biology or related discipline, with B.S.+5/M.S.+3 years’ industry research experience.
  • Experience with in vitro immunological assays (multi-parameter flow cytometry, immune cell sorting and isolation, etc.)
  • Experience with FlowJo, GraphPad Prism, or similar statistical software is preferred
  • Able to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines
  • Experience with Myeloid Cell Biology and human myeloid cell assays is a plus
  • Excellent attention to detail, strong documentation skills, and ability to communicate effectively (both written and verbal), required

Statement

Jounce Therapeutics is an equal opportunity employer and does not discriminate in its employment decisions on the basis of race, color, national origin, age, physical or mental disability, marital status, religion, creed, sex, or political beliefs.  We offer a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the U.S.

Company Summary

Jounce Therapeutics, Inc. is a clinical-stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long-lasting benefits to patients through a biomarker-driven approach. Jounce currently has multiple development stage programs ongoing while simultaneously advancing additional early-stage assets from its robust discovery engine based on its Translational Science Platform. Jounce’s highest priority program, JTX-8064, is a LILRB2 (ILT4) receptor antagonist shown to reprogram immune-suppressive tumor associated macrophages to an anti-tumor state in preclinical studies. A Phase 1 clinical trial, named INNATE, for JTX-8064 as a monotherapy and in combination with JTX-4014, Jounce’s internal PD-1 inhibitor, or pembrolizumab is currently enrolling patients with advanced solid tumors. Jounce’s most advanced product candidate, vopratelimab, is a monoclonal antibody that binds to and activates ICOS, and is currently being studied in the SELECT Phase 2 trial. JTX-4014 is a PD-1 inhibitor intended for combination use in the INNATE and SELECT trials and with Jounce’s broader pipeline. Additionally, Jounce exclusively licensed worldwide rights to JTX-1811, a monoclonal antibody targeting CCR8 and designed to selectively deplete T regulatory cells in the tumor microenvironment, to Gilead Sciences, Inc. For more information, please visit www.jouncetx.com.

Options

Sorry the Share function is not working properly at this moment. Please refresh the page and try again later.
Share on your newsfeed