• Director, Translational Science, Immuno-oncology

    Job ID
    2018-1162
    Category
    Research & Development
    Job Location
    US-MA-Cambridge
  • Company Summary

    Jounce Therapeutics, Inc. is a clinical stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long‑lasting benefits to patients. Through the use of its Translational Science Platform, Jounce first focuses on specific cell types within tumors to prioritize targets, and then identifies related biomarkers designed to match the right therapy to the right patient. Jounce’s lead product candidate, JTX-2011, is a monoclonal antibody that binds to and activates ICOS and is currently in the Phase 2 portion of the Phase 1/2 ICONIC trial. For more information, please visit www.jouncetx.com.

    Role / Responsibilities

    Translational Science is integral part of Jounce Therapeutics’ approach to developing new medicines for Immuno-Oncology. We are seeking an experienced translational biologist who is also a natural people leader and mentor to contribute towards target validation and biomarker development efforts at Jounce Therapeutics. The successful translational biologist is expected to transform the biology, genomics and bioinformatics knowledge into predictive and pharmacodynamic biomarkers as well as identification of novel molecular targets in the immuno-oncology field.

     

    Responsibilities:

    • Lead and mentor a group of experienced scientists engaged in experimental genomics, bioinformatics and translational strategy work.
    • Work effectively in, and foster, a cross-functional project team approach in a multi-disciplinary environment.
    • Help integrate basic science research, genomics and informatics to move programs into clinic as well as reverse engineer clinical findings to identify biomarkers and novel discovery opportunities.
    • Represent the Translational Genomics/Informatics group at project teams and research leadership team.
    • Work closely with discovery and research groups to plan and execute genetic analysis and biomarker identification for novel oncology targets.
    • Create and champion biomarker strategies within the company, including mentoring team members to author sections of protocols, biomarker reports, and agency submissions.
    • Provide leadership in the integrative analysis of gene expression, flow cytometry, protein, and drug response data for baseline and postdose biomarker discovery for preclinical and clinical programs.
    • Assist and direct team members in analysis of clinical data with molecular correlates such as mutation, gene expression signatures and IHC markers.
    • Manage work at external CROs including developing scope of work documents and evaluating quality of execution.
    • Develop, manage, and be accountable for yearly budget for translational group.

    Qualifications

    • A PhD in genomics, systems biology, computational biology, or bioinformatics with more than 10 years of industry experience.
    • Experience with mentoring and leading laboratory and informatics staff, in the context of cross functional team environment.
    • Demonstrated excellence in building and leading high productivity teams is a must.
    • Demonstrated background in immuno-oncology and drug development.
    • Extensive working knowledge of translational research and genomic methodologies.
    • Experience in clinical biomarker discovery is must. Preference will be given to candidates with experience in companion diagnostics.
    • Experience in investigating immunology or cancer immunotherapy gene expression analysis is essential.
    • Familiarity with statistical analysis for biomarkers (R, MATLAB, SAS, JMP).
    • Excellent oral and written skills.
    • Ability to prioritize and manage time efficiently.

    Statement

    Jounce Therapeutics is an equal opportunity employer and does not discriminate in it’s employment decisions on the basis of race, color, national origin, age, physical or mental disability, marital status, religion, creed, sex, or political beliefs.  We offer a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the U.S.

     

     

    To apply, please visit https://careers-jouncetx.icims.com/.

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