• Scientist, Antibody Discovery & Protein Engineering

    Job ID
    Research & Development
    Job Location
  • Company Summary

    Jounce Therapeutics, Inc. is a clinical stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long‑lasting benefits to patients. Through the use of its Translational Science Platform, Jounce first focuses on specific cell types within tumors to prioritize targets, and then identifies related biomarkers designed to match the right therapy to the right patient. Jounce’s lead product candidate, JTX-2011, is a monoclonal antibody that binds to and activates ICOS and is currently in the Phase 2 portion of the Phase 1/2 ICONIC trial. For more information, please visit www.jouncetx.com.

    Role / Responsibilities

    The Antibody Discovery and Protein Engineering group at Jounce Therapeutics is looking for an exceptional scientist in antibody discovery and engineering.   The successful candidate will play a critical role in the discovery and development of novel biotherapeutics for immuno-oncology at Jounce Therapeutics.  In this role you will be responsible for leading antibody discovery and screening campaigns to obtain a diversified set of therapeutic leads.  Additionally, you will execute laboratory research and design structure-based antibody and protein engineering solutions to optimize lead molecules.  You will also drive innovative technologies to enable deep antibody repertoire screening from immunized hosts.  This is an opportunity to work cross-functionally as part of Jounce research program teams and make an impact on the company pipeline.



    • Support the therapeutic strategy and design antibody discovery strategies using a variety of techniques (hybridoma/display/B cell selection) through internal and external research
    • Perform screening assays for therapeutic lead selection, including the use of high throughput robotics
    • Characterize target proteins and interactions using cell and protein binding techniques
    • Design and test engineering solutions using computational and structure-based design (humanization, liability corrections, multi-specific formatting and innovative protein fusion designs)


    • PhD in molecular biology, protein/antibody engineering, immunology, or related fields with 0-3 years postdoctoral biologics experience preferred, or BS/MS with 7+ years of relevant experience
    • Experience with protein engineering and structure-based design, required
    • Experience with antibody discovery technologies, repertoire analyses, and protein binding assays (flow cytometry/ForteBio Octet/ELISA/Biacore) preferred
    • Excellent attention to detail, strong documentation skills, and ability to communicate effectively (both written and verbal)


    Jounce Therapeutics is an equal opportunity employer and does not discriminate in it’s employment decisions on the basis of race, color, national origin, age, physical or mental disability, marital status, religion, creed, sex, or political beliefs.  We offer a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the U.S.



    To apply, please visit https://careers-jouncetx.icims.com/.


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