• Research Associate/Associate Scientist, Preclinical Sciences

    Job ID
    2018-1157
    Category
    Research & Development
    Job Location
    US-MA-Cambridge
  • Company Summary

    Jounce Therapeutics, Inc. is a clinical stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long‑lasting benefits to patients. Through the use of its Translational Science Platform, Jounce first focuses on specific cell types within tumors to prioritize targets, and then identifies related biomarkers designed to match the right therapy to the right patient. Jounce’s lead product candidate, JTX-2011, is a monoclonal antibody that binds to and activates ICOS and is currently in the Phase 2 portion of the Phase 1/2 ICONIC trial. For more information, please visit www.jouncetx.com.

    Role / Responsibilities

    We are looking for a creative and highly motivated research associate/associate scientist to join the Preclinical Sciences department at Jounce Therapeutics.  The successful candidate will be an integral part of a team of scientists supporting the preclinical and clinical development of novel cancer biologics.  Primary responsibilities include the development of immunoassays for the analysis of PK/PD and properties of molecules currently in the Jounce pipeline.  In addition, you will be involved in designing and developing cell-based, mechanistic assays to support preclinical research and clinical development.  The candidate will be responsible for the proper design and execution of experiments, data analysis and interpretation, thorough documentation of work, and clear communication of results both in group settings and in written reports. If you are a highly-motivated self-starter who likes working on innovative research projects and collaborative teams, this is the job for you!

     

    Responsibilities:

    • Development and execution of bioanalytical and cell-based immunoassays to support development of novel immunotherapies from research through to clinical development stage.
    • Thorough documentation of experiments and communication of results across functional teams.
    • Drafting documents in support of regulatory filings.
    • Mentoring junior staff members.

    Qualifications

    • S. or M.S. with 0-2 years of relevant laboratory experience in immunology or a related field. Industrial experience preferred.
    • Experience and comfort with the isolation of immune cells from blood and tissue, testing therapeutics in cellular assays, and phenotyping of immune cells.
    • Ability to work with tissue and blood or blood products.
    • Experience and comfort in developing, troubleshooting and qualifying bioanalytical assays to assess pharmacokinetics, ADA responses, and target engagement.
    • Extensive hands-on experience with immunological techniques including multi-parameter flow cytometry, single-cell sorting, immunoassays such as ELISA/MSD, in vitro cytotoxicity assays (ADCC & CDC), and reporter bioassays development.
    • Proficient at independently designing and executing experiments, analyzing data, and reporting conclusions to team members.
    • Experience in application of a variety of technologies, data analysis packages such as Prism, FlowJo, and other tools to analyze a variety of analytical data.
    • Excellent communication, organization and time management skills.
    • Ability to thrive in a highly collaborative, fast-paced, team-oriented environment with colleagues from diverse disciplines.
    • Familiarity working in GxP environments is a plus.

    Statement

    Jounce Therapeutics is an equal opportunity employer and does not discriminate in it’s employment decisions on the basis of race, color, national origin, age, physical or mental disability, marital status, religion, creed, sex, or political beliefs. 

     

    We offer a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the U.S.

     

    To apply, please visit https://careers-jouncetx.icims.com/.

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