• Associate Scientist/Scientist, Protein Analytics

    Job ID
    2018-1153
    Category
    Research & Development
    Job Location
    US-MA-Cambridge
  • Company Summary

    Jounce Therapeutics, Inc. is a clinical stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long‑lasting benefits to patients. Through the use of its Translational Science Platform, Jounce first focuses on specific cell types within tumors to prioritize targets, and then identifies related biomarkers designed to match the right therapy to the right patient. Jounce’s lead product candidate, JTX-2011, is a monoclonal antibody that binds to and activates ICOS and is currently in the Phase 2 portion of the Phase 1/2 ICONIC trial. For more information, please visit www.jouncetx.com.

    Role / Responsibilities

    The Protein Analytical group at Jounce Therapeutics is looking for an individual with expertise in protein therapeutics, especially in the fields of antibody characterization/developability assessment and protein affinity determination.   This is an exciting opportunity to play an important role in the discovery and development of novel biotherapeutics for immuno-oncology.  The successful candidate will be the protein analytical lead on project teams, lead experimental design, conduct experiments, optimize throughput, maintain detailed records, and generate standard operating procedures.  In this role you will have the opportunity to work cross functionally across multiple departments including discovery/biology, pre-clinical, Ab technology, protein production and CMC.

    The candidate will have strong protein biochemistry and antibody discovery knowledge and be proficient at designing and executing lab experiments.

    Responsibilities include:

    • Act as key point person in affinity determination and protein characterization/developability assessment teams
    • Be the protein analytical lead on project team to provide analytical support and participate in project meetings.
    • Monitor and maintain equipment and instruments regularly to ensure proper operation and calibration.
    • Prepare SOPs and reports

    Qualifications

    • MS with 5+ years’ or PhD with 0 to 2 years’ industrial experience in protein biochemistry/biophysics fields.
    • Strong knowledge of surface-, solution- and cell-based affinity determination methods.
    • Expertise in SPR and Octet. Good understanding ELISA and MSD. Hands-on experience with MASS-2 is a plus.
    • Hands-on experience with 2 or more of the following techniques: H/UPLC, DSC, DLS, SEC-MALS, icIEF, and CE-SDS techniques.
    • Experience with antibody discovery, developability assessment and characterization.
    • Excellent bench skills and strong documentation skills.
    • Strong attention to detail and generating quality data.
    • Team player with good communication skills and ability to work cross functionally

    Statement

    Jounce Therapeutics is an equal opportunity employer and does not discriminate in it’s employment decisions on the basis of race, color, national origin, age, physical or mental disability, marital status, religion, creed, sex, or political beliefs.  We offer a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the U.S.

     

     

    To apply, please visit https://careers-jouncetx.icims.com/.

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