• Scientist, Protein Production Group

    Job ID
    2018-1151
    Category
    Research & Development
    Job Location
    US-MA-Cambridge
  • Company Summary

    Jounce Therapeutics, Inc. is a clinical stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long‑lasting benefits to patients. Through the use of its Translational Science Platform, Jounce first focuses on specific cell types within tumors to prioritize targets, and then identifies related biomarkers designed to match the right therapy to the right patient. Jounce’s lead product candidate, JTX-2011, is a monoclonal antibody that binds to and activates ICOS and is currently in the Phase 2 portion of the Phase 1/2 ICONIC trial. For more information, please visit www.jouncetx.com.

    Role / Responsibilities

    The Protein Production group at Jounce Therapeutics is looking for an individual experienced in molecular biology, mammalian cell culture, protein purification, and characterization.  The successful candidate will play an important role in the discovery and development of novel biotherapeutics for immuno-oncology as part of a small, highly dedicated team.  He/she will be will be responsible for the production and purification of antibodies and proteins for use in R&D that will enable the development of groundbreaking therapies.  He/she will be expected to participate in experimental design, conduct experiments, optimize throughput, maintain detailed records, generate standard operating procedures, and be a leader in and out of the lab. This is an exciting opportunity to be part of a fast-paced cross-functional environment in the dynamic field of immuno-oncology.

     

    Responsibilities may include, but are not limited to:

    • Protein purification steps including affinity chromatography, IEX, SEC, etc. GE AKTA FPLCs
    • Transient and stable protein production in mammalian cells
    • Protein quality control – SE-HPLC, SDS-PAGE, endotoxin assays
    • Determination of binding affinities
    • Developing methods for automating cell culture transfection, protein purification and screening assays in high throughput fashion using liquid handling robots
    • Cross-functional training/coordination with the CMC and Cell Line Development groups
    • Leadership opportunities as functional area representative on Project Teams
    • Train and mentor junior staff members and coops in the lab
    • Thorough documentation and cross-functional communication

    Qualifications

    • BS, M.S., or Ph.D. in biochemistry, bioengineering, or a related discipline
    • 5-10 years (B.S. or M.S) or 0-3 years (Ph.D) of biotech/pharma industry experience.
    • Extensive experience with multi-step protein purification techniques using GE’s AKTA systems and Unicorn software, and diverse chromatography methods, required
    • Experience with analyzing proteins (SE-HPLC, endotoxin assays, SDS-PAGE, Western Blots), required
    • Experience with mammalian cell culture, transient and stable mammalian (CHO and HEK) protein expression, and aseptic techniques, preferred
    • Experience with downstream process development, a plus
    • Ability to work with LIMS and biological registration systems as well as electronic lab notebook software, required
    • Excellent attention to detail, strong documentation skills, drive to work in a fast-paced environment, and ability to communicate effectively (both written and verbal), required

    Statement

    Jounce Therapeutics is an equal opportunity employer and does not discriminate in it’s employment decisions on the basis of race, color, national origin, age, physical or mental disability, marital status, religion, creed, sex, or political beliefs.  We offer a competitive salary and benefits package. All applicants should be legally entitled to work for any employer in the U.S.

     

     

    To apply, please visit https://careers-jouncetx.icims.com/.

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