Director of Clinical Pharmacology

Job ID
Clinical Development
Job Location

Company Summary

Jounce Therapeutics, Inc. is a clinical stage immunotherapy company dedicated to transforming the treatment of cancer by developing therapies that enable the immune system to attack tumors and provide long‑lasting benefits to patients. Through the use of its Translational Science Platform, Jounce first focuses on specific cell types within tumors to prioritize targets, and then identifies related biomarkers designed to match the right therapy to the right patient. Jounce’s lead product candidate, JTX-2011, is a monoclonal antibody that binds to and activates ICOS and is currently in a Phase 1/2 trial. For more information, please visit

We have many career opportunities at Jounce and are looking for exceptional individuals who share our passion and perseverance for developing highly durable cancer immunotherapies that can dramatically impact and improve patients’ lives.

Role / Responsibilities

Summary: The Head of Clinical Pharmacology will have a pivotal role in providing strategic clinical pharmacology guidance on our drug development, including modeling to support FIH dose, and development and execution of plans to analyze PK, ADA, drug interaction studies, pharmacodynamics, and population PK. The candidate will possess strong writing capabilities, be able to contribute to non- clinical and clinical protocols, statistical analysis plans, clinical study reports, abstracts and presentations for scientific and medical meetings, and briefing documents for regulatory agencies from INDs through BLAs. The candidate will bring extensive experience in oncology, quantitative pharmacology (both clinical and non-clinical experience), and work cross-functionally research and clinical teams to drive our programs to success.



  • Oversee program progression as it relates to clinical pharmacology, including protocol conduct, data analysis, internal decision points and external regulatory interactions
  • Manage and be accountable for pharmacokinetic, pharmacodynamic, drug interaction, and anti- drug antibody data for all clinical trials
  • Work closely with cross functional teams and be the subject matter expert in quantitative clinical pharmacology, non-clinical pharmacology, and non-clinical modeling to determine FIH dose and schedule
  • Contribute to program strategy, study design, protocol preparation, study execution, data review/analysis, study reports and regulatory document preparation
  • Work closely with biology and analytical teams and provide input into assay development, CRO selection and CRO management
  • Represent nonclinical and clinical pharmacology during meetings and discussions with regulatory authorities
  • Create or guide nonclinical and clinical pharmacology summary documents
  • Review literature and peer-reviewed publications to keep apprised of global regulatory developments, including guidance and recommendations, in clinical pharmacology
  • Maintain a high standard for good laboratory and clinical practices, compliance, and ethical standards
  • Act collaboratively, with constant exchange of ideas, to advance innovation


  • PhD with at least 10 years of relevant nonclinical and clinical pharmacology experience supporting early and late-stage drug development and IND, NDA, BLA and MAA applications within the pharmaceutical and biotechnology industry
  • Demonstrated experience in writing, presenting, and discussing nonclinical and clinical py with both internal and external stakeholders, including regulatory authoritiesharmacolog
  • Strong analytical skills and ability to interpret complex nonclinical and clinical data sets
  • Proven ability to engage in discourse involving innovative drug discovery
  • Demonstrated ability to thrive in a fast-paced, intense environment
  • Team player who engages with subject matter experts across functions to elevate the level of scientific and clinical investigation
  • Software experience in WINNONLIN, NONMEM, SAS, JMP, S-Plus, and/or R


To apply, please visit 


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