Director of Antibody Generation and Protein Engineering

Job ID
Research & Development
Job Location

Company Summary

This role will guide efforts in the generation of biologic leads derived from discovery and optimization platforms for the development of novel therapeutics. In this position you will manage a team of scientists in support of therapeutic programs focused in immuno-oncology. This role requires direct expertise in antibody generation from immunogen selection through selection of best platform to enable creation of a broad panel of potential antibody candidates, antibody screening methodologies, and the engineering and optimization of lead candidates.  In addition, the preferred candidate will also have knowledge of biologic topologies, platform technologies, and developability assessment for lead candidate selection.

Role / Responsibilities

  • Provide strong leadership to a group of 6 scientists (PhD and non-PhD) in an environment of commitment to generate drugs that create transformative, long-lasting cancer immunotherapies
  • Lead discovery and protein engineering activities including devising best strategies to generate, screen and optimize biologics for functional activity and manufacturability
  • Responsible for identifying and managing the design and implementation of technology development projects in the field of antibody and protein engineering
  • Work closely in a cross-functional program team environment with Heads of Protein Production and Protein Analytics as well as Research Scientists across multiple projects to support various discovery, preclinical, and translational efforts and ensure timelines and goals are met
  • In collaboration with other groups, oversee analysis and interpretation of data, disseminate key results and provide regular project status updates
  • Work closely with leaders in Discovery, Translational, and CMC to expedite development of candidates from Discovery to IND
  • Evaluate technology platforms for potential partnering or licensing opportunities


  •  PhD in Biochemistry, Chemical Engineering, or related field
  • 10+ yrs industry experience in antibody generation and engineering with demonstrated expertise in biologic drug discovery and optimization including through use of novel protein engineering platforms
  • Experience with antibody technology platforms including hybridoma, transgenic hosts, and display platforms with working knowledge of other modalities (e.g fusion proteins or vaccines) an advantage
  • Proven track record of leading, coaching and developing high functioning teams to identify, screen and engineer novel therapeutics from discovery to IND
  • Strong relationship building and communication skills to empower teams and leverage strengths
  • Ability to work in fast-paced, cross-functional program-team environment
  • Effective management of CROs and technology platforms to deliver diverse panels of lead candidates for internal evaluation
  • Ability to work closely with leads across departments in Research to facilitate communication, transparency, efficient decision making and problem solving


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